Albendazole, also known as albendazolum, is a medication used for the treatment of a variety of parasitic worm infestations. It is useful for giardiasis, trichuriasis, filariasis, neurocysticercosis, hydatid disease, pinworm disease, and ascariasis, among others. It is taken by mouth.
Class of Drug
Mechanism of Action
Inhibits uptake of glucose and other nutrients by parasitic helminths.
Indications / Dosage / Route
Routes of Administration: Oral only.
Condition: Hydatid disease
Dose: Adults > 60 kg: 400 mg b.i.d. with meals, 28-hour cycle followed by 14-day drug-free interval for total of 3 cycles.
Adults <60 kg: 15 mg/kg/d in divided doses b.i.d. with meals. Maximum total daily dose: 800 mg.
Dose: Adults > 60 kg: 400 mg b.i.d. with meals, 8-30 days.
Adults < 60 kg: 50 mg/kg/d in divided doses b.i.d. with meals. Maximum total daily dose: 800 mg.
Food and Drug Interactions
Food: Take with food.
Pregnancy: Category C.
Lactation: Probably present in breast milk. Best to avoid.
Contraindications: Hypersensitivity to mabendazole.
> Common: Diarrhea, Abdominal pain, Nausea, Vomiting.
> Serious: bone marrow suppression, hepatitis, hypersensitivity reactions.
Advice to Patient
> Avoid driving and other activities requiring mental alertness or that are potentially dangerous until response to drug is known.
> Patient and family members should shower frequently if possible
> Keep hands away from mouth.
> Keep fingernails short and clean.
> Do not shake bedding as this could result in airborne spread of ova.
> Counsel patient’s family members to check for worm infesta-tion and treat accordingly.
> Disinfect toilet daily; wash all fruits and vegetables; cook all meats and vegetables thoroughly.
> Wear gloves when preparing food.
Further Useful Info
> Patient and family members should be taught how to avoid reinfestation with these worms. The following measures should be undertaken to avoid reinfection: (1) perianal area should be washed thoroughly (2) hands and fingernails should be cleaned before meals and after defecation (3) undergarments and bedclothes should be changed daily.
> For those treated for hookworm and whipworm: it may be necessary to take an iron supplement every day and for 6 months following treatment if anemia is present.