Diclofec - Non-Steroidal Antiinflammatory Drug (NSAID)

Diclofenac is a Non-Steroidal Anti-Inflammatory Drug (NSAID) which is most commonly used for reducing Inflammation. It also serves as Analgesic and used to treat pain in certain conditions.


Molecular Structure

Diclofec - Non-Steroidal Antiinflammatory Drug (NSAID)

Class of Drug

Non-Steroidal Anti-Inflammatory Drug (NSAID)

Mechanism of Action

Inhibits cyclooxygenase, resulting in inhibition of synthesis of prostaglandins and other inflammatory mediators.


Indications / Dosage / Route

Routes of Administration: Oral, Topical (in the form of Gels and Sprays) and Ophthalmic.

Condition: Analgesia, Primary Dysmenorrhea

Dose: Adults – Oral (PO) 50 mg T.I.D (Three times in a day) – Max 150 mg / Day

Condition: Rheumatoid Arthritis

Dose: Adults – Oral (PO) 50 mg T.I.D or Q.I.D (4 times a day)

If the condition is chronic then use Extended Release Tablets 100 mg QD (once in a day) or B.I.D (Twice a day) – Max 225 mg / Day

Condition: Osteoarthritis

Dose: Adults – Oral (PO) 50 mg B.I.D or T.I.D

If the condition is chronic then use Extended Release Tablets, 100 mg / Day. Max: 200 mg / Day.

Condition: Ankylosing Spondylitis

Dose: Adults – Oral (PO) 25 mg Q.I.D (4 times in a Day). Max: 125 mg / Day.

Ophthalmic Solution:

Condition: Following cataract surgery

Dose: 0.1%, 1 drop in affected eye Q.I.D (4 times in a Day) – 24 hours after cataract surgery.

Adjustment of Dosage

Kidney disease: None.

Liver disease: None.

Elderly: May be necessary to reduce dose for patients >65 years.

Pediatric: Safety and efficacy have not been established.


Food and Drug Interactions

Food: Take with food or large quantities of water or milk.

Pregnancy: Category B. Category D in third trimester or near delivery.

Lactation: May appear in breast milk. Breastfeeding considered to be low risk by some authors.

Drug Interactions: Hypersensitivity and cross-sensitivity with other NSAIDs and aspirin.

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